Research

Department of Power Mechanical Engineering @ National Tsing Hua University

We focus on Microsystem and Lab Chip

where Engineering meets Nano/Micro, Bio and Medicine

Bio/Medical/LabChip Microsystems Research Projects

	Dynamic manipulation and patterning of microparticles and cells by using TiOPc-based optoelectronic dielectrophoresis(actively developing)

	Cell patterning Labchip for tissue engineering applications - Liver on a chip(actively developing)

	Integrated Biochip for Clinical Disease detection(actively developing)

	Programmable Bio-sorting Microsystem Chip using Enhanced DEP Array

Chemotaxis(actively developing)


	Micro Cell Cytometry(actively developing)

Biomimetic/Microfluidics Microsystems (for Energy and Biomedical Applications) Research Projects

	Electrolysis-Bubble-Actuated Micropump (actively developing)

	Biomimetic Actuator Array for Bio-object Manipulation

Microfluidic Driver via AC Electrokinetics(actively developing)


	Electrokinetic Micromixer

Micro Fluidic Switches via the Control of Capillary Effect


	Roughness-Gradient-Electrolysis-Bubble-Actuated Micropump

Bubble-activated Micropump with High-frequency Flow Reversal

Optical System on a Chip (for Display, Telcom and Biomedical Applications) and MicroSensor

Research Projects

Pitch tunable blaze grating


	Variable Optical Attenuator


	Fiber Optical Tweezers


	Optical Switch


	Quantum Electron Tunneling Sensor

Research Achievement Highlights

On-chip Blood Transportation Using Air-bubble – Research was highlighted by RSC Chemical Technology, 2009 and entitled “Microfluidics pumps it up” and showed on You Tube Lab on Chip video channel. A paper was selected as an inside front cover image of Lab on a chip journal as well as a hot article of Lab on a chip journal.

Liver on Lab Chip -- Our Liver Chip research was highlighted by RSC Chemical Biology, June 7, 2006 and entitled Liver on a chip. A paper was selected as a cover image of Lab on a chip journal as well as a hot article of Lab on a chip journal.

Liver on Lab Chip Program – our three-year team research program (capturing liver functions in-vitro and biomedical studies) has been approved and supported by The Taiwan National Science and Technology Program for Nanoscience and Nanotechnology for the period of 2008 through 2011.

On-chip Blood Transportation Using Air-bubble – Inside Cover of Lab on a chip Journal, 2009 (to be published)
High-performance MEMS Accelerometer via Quantum Electron Tunneling -- High-precision MEMS accelerometers based on Quantum electron tunnelling effect have been developed by with the resolution of 20 nano-g/ and a 5 Hz-1.5 kHz bandwidth, which worldwide MEMS accelerometer researchers (EE at U. Michigan, EE and ME at UC Berkeley, EE at Cornell U., EE at Stanford, EE at Tokyo U., JPL, researchers in Europe, and many other famous groups) and industry have never achieved/reported up to the paper publication day. Two published J. MEMS papers have been cited by other researchers’ papers, which are not from my current group and my former Ph.D. study group, at least 70 times up to date. One American Control Conference paper was selected as one of five best papers for best student papers competition.
Liquid-surface-tension actuated Micropump -- Borrow partial actuation force from God. Research was published on Journal of MicroElectroMechanical Systems and highlighted by SPIE Newsroom, May 2007

Lobster-sniffing Inspired Biomimic Actuator -- We are the first group worldwide to initiate this research, lobster-sniffing inspired actuator for micro-particle manipulation in liquid, as well as the first group to preliminarily demonstrate the feasibility. Besides journal publications, our Transducers05 oral paper was referred as one of three papers for discussion and study at MIT MEMS/NEMS journal club on Aug. 2005.
Cell Sorter BioMEMS -- One published journal paper was selected as a Hot Article for Lab on a Chip journal. The following is quoted from Hot Article Interview of Lab on a Chip regarding our paper - “This research proposes a non-invasive control method for cells in the microfluidic flow pathways on a monolithic chip, which will be significant for purifying the sensitive stem cells from other cells without extra stimulation.”

Research Project Sponsors
National Science and Technology Program for Nanoscience and Nanotechnology, National Science Council, Raydium/BenQ, Test Research Inc., ITRI, OPUS Microsystems, UST Nano Research Center, UST Brain Research Center, Taiwan Semiconductor Manufacturing Company, Dr. Chip Biotech Inc., Cando Corp., Asia Pacific Microsystems, Sinica etc.